Article
Memory T cells in the chronic inflammatory microenvironment of nasal polyposis are hyporesponsive to signaling through the T cell receptor.
Journal of the Association for Research in Otolaryngology : JARO - 1 Jun 2012
Lehman Heather K, Simpson-Abelson Michelle R, Conway Thomas F, Kelleher Raymond J, Bernstein Joel M, Bankert Richard B
Abstract excerpt
A majority of T cells from chronic inflammatory tissues derived from patients with nasal polyposis were found to express an effector memory phenotype. We report here that these memory T cells failed to activate NF-κB in response to TCR stimulation but responded normally when the proximal TCR signaling molecules were bypassed with PMA and ionomycin. The dysfunction of these cells was associated with a decrease in...
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