[Obtaining and characteristic of Streptomyces globisporus 1912 mutants with high biosynthesis of landomycin e].

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Article

[Obtaining and characteristic of Streptomyces globisporus 1912 mutants with high biosynthesis of landomycin e].

Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993) - 1 Jan 2000

Lavrinchuk B Ia, Kotenko K A, Golembiovs'ka S L, Matseliukh B P

Abstract excerpt

Eight highly productive UV-induced mutants of Streptomyces globisporus 1912 with high biosynthesis of landomycin E were isolated, their isolation frequency being 2 x 10(-3). Mutants 1-1, 1-4-1, 1-1y, 1-2y, 4-1, 1-2 produced 175-187.5 mg of landomycine E and 1-1b, 4-1-1 and 1-3--80-100 mg per 1 liter of soybean agar after 48 hours of cultivation The mutant 4-1-1 had the highest antibiotic activity and middle level...

Topics

Aminoglycosides
Antineoplastic Agents
Chromatography, Thin Layer
Color
Culture Media
Humans
Mutation
Neoplasms
Oxidation-Reduction
Streptomyces
Ultraviolet Rays

Source

Open in PubMed

Identifiers

PMID: 22308749

Provenance

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