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Article

RAP80 binds p32 to preserve the functional integrity of mitochondria.

Biochemical and biophysical research communications - 21 Oct 2017

Chung Hee Jin, Korm Sovannarith, Lee Se-In, Phorl Sophors, Noh Solhee, Han Miae, Naskar Rema, Kim Hongtae, Lee Joo-Yong

Abstract excerpt

RAP80, a member of the BRCA1-A complex, is a well-known crucial regulator of cell cycle checkpoint and DNA damage repair in the nucleus. However, it is still unclear whether Rap80 localizes to another region outside the nucleus and plays different roles with its partners. Here, we found mitochondrial p32 as a novel binding partner of RAP80 by using yeast two-hybrid screening. RAP80 directly binds the internal...

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Identifiers

PMID: 28842250
DOI: 10.1016/j.bbrc.2017.08.077

Genes

BRCA1

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