Article
Homeobox gene distal-less is required for neuronal differentiation and neurite outgrowth in the Drosophila olfactory system.
Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 2012
Plavicki Jessica, Mader Sara, Pueschel Eric, Peebles Patrick, Boekhoff-Falk Grace
Abstract excerpt
Vertebrate Dlx genes have been implicated in the differentiation of multiple neuronal subtypes, including cortical GABAergic interneurons, and mutations in Dlx genes have been linked to clinical conditions such as epilepsy and autism. Here we show that the single Drosophila Dlx homolog, distal-less, is required both to specify chemosensory neurons and to regulate the morphologies of their axons and dendrites. We...
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