Antisense inhibition of glial S100 beta production results in alterations in cell morphology, cytoskeletal organization, and cell proliferation.

doi:10.1083/jcb.111.5.2021

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Article

Antisense inhibition of glial S100 beta production results in alterations in cell morphology, cytoskeletal organization, and cell proliferation.

The Journal of cell biology - 1 Nov 1990

Selinfreund R H, Barger S W, Welsh M J, Van Eldik L J

Abstract excerpt

The phenotypic effects of selectively decreasing the levels of S100 beta in cultured glial cells were analyzed. Two separate antisense approaches were utilized for inhibition of S100 beta production: analysis of clonal isolates of rat C6 glioma cells containing an S100 beta antisense gene under the control of a dexamethasone-inducible promoter, and analysis of C6 cells treated with S100 beta antisense...

Topics

Animals
Base Sequence
Cell Division
Clone Cells
Cytoskeleton
Dexamethasone
Gene Expression Regulation
Glioma
Molecular Sequence Data
Nerve Growth Factors
Neuroglia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotides, Antisense

Phenotype

Promoter Regions, Genetic

Rats

S100 Calcium Binding Protein beta Subunit

S100 Proteins

Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 2229184
DOI: 10.1083/jcb.111.5.2021
PMCID: PMC2116346

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2229184-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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