Article
Alterations of OprD in carbapenem-intermediate and -susceptible strains of Pseudomonas aeruginosa isolated from patients with bacteremia in a Spanish multicenter study.
Antimicrobial agents and chemotherapy - 1 Apr 2012
Ocampo-Sosa Alain A, Cabot Gabriel, Rodríguez Cristina, Roman Elena, Tubau Fe, Macia María D, Moya Bartolomé, Zamorano Laura, Suárez Cristina, Peña Carmen, Domínguez María A, Moncalián Gabriel, Oliver Antonio, Martínez-Martínez Luis
Abstract excerpt
We investigated the presence of OprD mutations in 60 strains of metallo-ß-lactamase-negative Pseudomonas aeruginosa intermediately susceptible (IS [n = 12]; MIC = 8 μg/ml) or susceptible (S [n = 48]; MICs ≤ 1 to 4 μg/ml) to imipenem and/or meropenem that were isolated from patients with bacteremia in order to evaluate their impact on carbapenem susceptibility profiles. The presence of mutations in oprD was...
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