Article
Routine use of microarray-based gene expression profiling to identify patients with low cytogenetic risk acute myeloid leukemia: accurate results can be obtained even with suboptimal samples.
BMC medical genomics - 30 Jan 2012
de la Blétière Diane Raingeard, Blanchet Odile, Cornillet-Lefèbvre Pascale, Coutolleau Anne, Baranger Laurence, Geneviève Franck, Luquet Isabelle, Hunault-Berger Mathilde, Beucher Annaelle, Schmidt-Tanguy Aline, Zandecki Marc, Delneste Yves, Ifrah Norbert, Guardiola Philippe
Abstract excerpt
BACKGROUND: Gene expression profiling has shown its ability to identify with high accuracy low cytogenetic risk acute myeloid leukemia such as acute promyelocytic leukemia and leukemias with t(8;21) or inv(16). The aim of this gene expression profiling study was to evaluate to what extent suboptimal samples with low leukemic blast load (range, 2-59%) and/or poor quality control criteria could also be correctly...
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