Article
Absence of nucleotide-binding oligomerization domain-containing protein 2 variants in patients with leprosy and tuberculosis.
International journal of immunogenetics - 1 Aug 2012
Singh V, Gaur R, Mittal M, Biswas S K, Das R, Girdhar B K, Bajaj B, Katoch V M, Kumar A, Mohanty K K
Abstract excerpt
Crohn's disease-associated NOD 2 variants (Arg702Trp and 3020insC) were found to be monomorphic (wild), and 7 subjects were heterozygous for Gly908Arg SNP in 263 patients with tuberculosis, 260 patients with leprosy and 270 healthy controls residing in northern Indian states. This is the first report to suggest the minimal role of these variants in susceptibility/resistance to TB and leprosy in this population.
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