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Article

Mutant mice derived by ICSI of evaporatively dried spermatozoa exhibit expected phenotype.

Reproduction (Cambridge, England) - 1 Apr 2012

Li Ming-Wen, Baridon Brian, Trainor Amanda, Djan Esi, Koehne Amanda, Griffey Stephen M, Biggers John D, Toner Mehmet, Lloyd K C Kent

Abstract excerpt

Apolipoprotein E (Apoe)-deficient knockout mice were used to test the hypothesis that mutant mice preserved as evaporatively dried (ED) spermatozoa, stored at -80 °C for 6 months, and then recovered by ICSI will exhibit the same phenotype as before preservation. The birth rate of mice recovered by ICSI of evaporatively dried spermatozoa was lower than that of fresh spermatozoa (17.5 vs 38.0%). Progeny of mice...

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Identifiers

PMID: 22274886
DOI: 10.1530/REP-12-0005
PMCID: PMC3738174

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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