Article
A functional NQO1 609C>T polymorphism and risk of gastrointestinal cancers: a meta-analysis.
PloS one - 1 Jan 2012
Yu Hongping, Liu Hongliang, Wang Li-E, Wei Qingyi
Abstract excerpt
BACKGROUND: The functional polymorphism (rs1800566) in the NQO1 gene, a 609C>T substitution, leading to proline-to-serine amino-acid and enzyme activity changes, has been implicated in cancer risk, but individually published studies showed inconclusive results. METHODOLOGY/PRINCIPAL FINDINGS: We...
Topics
- Gastrointestinal Neoplasms
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- NAD(P)H Dehydrogenase (Quinone)
- Polymorphism, Single Nucleotide
- Risk Factors