A functional NQO1 609C>T polymorphism and risk of gastrointestinal cancers: a meta-analysis.

doi:10.1371/journal.pone.0030566

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Article

A functional NQO1 609C>T polymorphism and risk of gastrointestinal cancers: a meta-analysis.

PloS one - 1 Jan 2012

Yu Hongping, Liu Hongliang, Wang Li-E, Wei Qingyi

Abstract excerpt

BACKGROUND: The functional polymorphism (rs1800566) in the NQO1 gene, a 609C>T substitution, leading to proline-to-serine amino-acid and enzyme activity changes, has been implicated in cancer risk, but individually published studies showed inconclusive results. METHODOLOGY/PRINCIPAL FINDINGS: We performed a meta-analysis of 20 publications with a total of 5,491 cases and 5,917 controls, mainly on gastrointestinal...

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Identifiers

PMID: 22272361
DOI: 10.1371/journal.pone.0030566
PMCID: PMC3260285

Genes

NQO1

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