Article
[Molecular diagnosis of retinoblastoma: molecular epidemiology and genetic counseling].
Medicina clinica - 25 Mar 2006
Alonso Javier, Palacios Itziar, Gámez Angelo, Camino Isabel, Frayle Helena, Menéndez Ibis, Kontic Milica, García-Miguel Purificación, Sastre Ana, Abelairas José, Sarret Enric, Sabado Constantino, Navajas Aurora, Artigas Mercé, Indiano José M, Carbone Ana, Rosell Jordi, Pestaña Angel
Abstract excerpt
BACKGROUND AND OBJECTIVE: Retinoblastoma, a prototype of hereditary cancer, is the most common intraocular tumor in children and a potential cause of blindness from therapeutic eye ablation, second tumors in germ line mutation carriers, and even death when untreated. The molecular scanning of RB1 in search of germ line mutations in 213 retinoblastoma patients from Spain, Cuba, Colombia and Serbia, has led to the...
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