Article
SSeCKS sequesters cyclin D1 in glomerular parietal epithelial cells and influences proliferative injury in the glomerulus.
Laboratory investigation; a journal of technical methods and pathology - 1 Apr 2012
Burnworth Bettina, Pippin Jeff, Karna Prasanthi, Akakura Shin, Krofft Ron, Zhang Guoqiang, Hudkins Kelly, Alpers Charles E, Smith Kelly, Shankland Stuart J, Gelman Irwin H, Nelson Peter J
Abstract excerpt
Glomerular parietal epithelial cells (PECs) are precursors to podocytes in mature glomeruli; however, as progenitors, the distinct intrinsic mechanisms that allow for repeated periods of cell-cycle arrest and re-entry of PECs after glomerulogenesis are unknown. Here, we show that the Src-suppressed protein kinase C substrate (SSeCKS), a multivalent scaffolding A kinase anchoring protein, sequesters cyclin D1 in...
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