Article
Genome-wide linkage meta-analysis identifies susceptibility loci at 2q34 and 13q31.3 for genetic generalized epilepsies.
Epilepsia - 1 Feb 2012
Leu Costin, de Kovel Carolien G F, Zara Federico, Striano Pasquale, Pezzella Marianna, Robbiano Angela, Bianchi Amedeo, Bisulli Francesca, Coppola Antonietta, Giallonardo Anna Teresa, Beccaria Francesca, Trenité Dorothée Kasteleijn-Nolst, Lindhout Dick, Gaus Verena, Schmitz Bettina, Janz Dieter, Weber Yvonne G, Becker Felicitas, Lerche Holger, Kleefuss-Lie Ailing A, Hallman Kerstin, Kunz Wolfram S, Elger Christian E, Muhle Hiltrud, Stephani Ulrich, Møller Rikke S, Hjalgrim Helle, Mullen Saul, Scheffer Ingrid E, Berkovic Samuel F, Everett Kate V, Gardiner Mark R, Marini Carla, Guerrini Renzo, Lehesjoki Anna-Elina, Siren Auli, Nabbout Rima, Baulac Stephanie, Leguern Eric, Serratosa Jose M, Rosenow Felix, Feucht Martha, Unterberger Iris, Covanis Athanasios, Suls Arvid, Weckhuysen Sarah, Kaneva Radka, Caglayan Hande, Turkdogan Dilsad, Baykan Betul, Bebek Nerses, Ozbek Ugur, Hempelmann Anne, Schulz Herbert, Rüschendorf Franz, Trucks Holger, Nürnberg Peter, Avanzini Giuliano, Koeleman Bobby P C, Sander Thomas
Abstract excerpt
PURPOSE: Genetic generalized epilepsies (GGEs) have a lifetime prevalence of 0.3% with heritability estimates of 80%. A considerable proportion of families with siblings affected by GGEs presumably display an oligogenic inheritance. The present genome-wide linkage meta-analysis aimed to map: (1) susceptibility loci shared by a broad spectrum of GGEs, and (2) seizure type-related genetic factors preferentially...
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