Article
Significance of C2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population.
Investigative ophthalmology & visual science - 16 Feb 2012
Nakata Isao, Yamashiro Kenji, Yamada Ryo, Gotoh Norimoto, Nakanishi Hideo, Hayashi Hisako, Akagi-Kurashige Yumiko, Tsujikawa Akitaka, Otani Atsushi, Saito Masaaki, Iida Tomohiro, Oishi Akio, Matsuo Keitaro, Tajima Kazuo, Matsuda Fumihiko, Yoshimura Nagahisa
Abstract excerpt
PURPOSE: To determine whether genetic variants in the complement component 2 and factor B gene (C2/CFB) locus are associated with the risk for typical age-related macular degeneration (AMD) or polypoidal choroidal vasculopathy (PCV) in a Japanese population. METHODS: Four single nucleotide polymorphisms (SNPs) were genotyped across the C2/CFB locus of patients with typical AMD (n = 455) or PCV (n = 581) and of...
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