Article
Immunophenotyping in systemic mastocytosis diagnosis: 'CD25 positive' alone is more informative than the 'CD25 and/or CD2' WHO criterion.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 2012
Morgado José Mário T, Sánchez-Muñoz Laura, Teodósio Cristina G, Jara-Acevedo Maria, Alvarez-Twose Iván, Matito Almudena, Fernández-Nuñez Elisa, García-Montero Andrés, Orfao Alberto, Escribano Luís
Abstract excerpt
Aberrant expression of CD2 and/or CD25 by bone marrow, peripheral blood or other extracutaneous tissue mast cells is currently used as a minor World Health Organization diagnostic criterion for systemic mastocytosis. However, the diagnostic utility of CD2 versus CD25 expression by mast cells has not been prospectively evaluated in a large series of systemic mastocytosis. Here we evaluate the sensitivity and...
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