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Article

[Immunohistochemical and molecular characterization of systemic mastocytoses].

Verhandlungen der Deutschen Gesellschaft fur Pathologie - 1 Jan 2005

Sotlar K

Abstract excerpt

The WHO has published an updated classification of mastocytosis and the criteria for the diagnosis of systemic mastocytosis (SM). These include one major criterion, compact mast cell (MC) infiltrates in extracutaneous tissues, and four minor criteria, i.e. cytomorphologic atypia with spindling of MC (>25 %), detection of the activating somatic c-kit mutation D816 V in MC, aberrant expression of CD2 and/or CD25 on...

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PMID: 18035698

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