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Article

A high-throughput cell-based screening for L858R/T790M mutant epidermal growth factor receptor inhibitors.

Anticancer research - 1 Jan 2012

Lin Wen-Hsing, Song Jen-Shin, Lien Tzu-Wen, Chang Chun-Yu, Wu Szu-Huei, Huang Yu-Wen, Chang Teng-Yuan, Fang Ming-Yu, Yen Kuei-Jung, Chen Chun-Hwa, Chu Chang-Ying, Hsieh Hsing-Pang, Chen Yi-Rong, Chao Yu-Sheng, Hsu John T-A

Abstract excerpt

A high-throughput 32D(L858R/T790M) cell-based assay to identify inhibitors of the L858R/T790M mutant epidermal growth factor receptor (EGFR) pathway was established. After screening, ten hits from among 60,000 compounds in our in-house compound library were initially identified. In the secondary assays, one hit, 1-[2-(decyloxy)-2-oxoethyl]-3-methyl-2-[(4-methylphenoxy) methyl]-1H-benzimidazol-3-ium, was confirmed...

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Identifiers

PMID: 22213300

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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