Article
Single nucleotide polymorphisms in the Toll-like receptor 3 and CD44 genes are associated with persistence of vaccine-induced immunity to the serogroup C meningococcal conjugate vaccine.
Clinical and vaccine immunology : CVI - 1 Mar 2012
Moore Catrin E, Hennig Branwen J, Perrett Kirsten P, Hoe J Claire, Lee Sue J, Fletcher Helen, Brocklebank Denise, O'Connor Daniel, Snape Matthew D, Hall Andrew J, Segal Shelley, Hill Adrian V S, Pollard Andrew J
Abstract excerpt
The rate of decay of antibody concentration following serogroup C meningococcal (MenC) polysaccharide-protein conjugate vaccination varies between individuals. This depends partly on vaccination age but may be influenced by human genetics. We studied 721 single nucleotide polymorphisms (SNPs) across 131 candidate genes in a first cohort of 905 Caucasians (11 to 21 years old; mean time after vaccination, 4.9...
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