Article
Extensive genetic diversity and substructuring among zebrafish strains revealed through copy number variant analysis.
Proceedings of the National Academy of Sciences of the United States of America - 10 Jan 2012
Brown Kim H, Dobrinski Kimberly P, Lee Arthur S, Gokcumen Omer, Mills Ryan E, Shi Xinghua, Chong Wilson W S, Chen Jin Yun Helen, Yoo Paulo, David Sthuthi, Peterson Samuel M, Raj Towfique, Choy Kwong Wai, Stranger Barbara E, Williamson Robin E, Zon Leonard I, Freeman Jennifer L, Lee Charles
Abstract excerpt
Copy number variants (CNVs) represent a substantial source of genomic variation in vertebrates and have been associated with numerous human diseases. Despite this, the extent of CNVs in the zebrafish, an important model for human disease, remains unknown. Using 80 zebrafish genomes, representing three commonly used laboratory strains and one native population, we constructed a genome-wide, high-resolution CNV map...
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