Article
Interleukin 32 (IL-32) contains a typical α-helix bundle structure that resembles focal adhesion targeting region of focal adhesion kinase-1.
The Journal of biological chemistry - 17 Feb 2012
Heinhuis Bas, Koenders Marije I, van den Berg Wim B, Netea Mihai G, Dinarello Charles A, Joosten Leo A B
Abstract excerpt
IL-32 can be expressed in several isoforms. The amino acid sequences of the major IL-32 isoforms were used to predict the secondary and tertiary protein structure by I-TASSER software. The secondary protein structure revealed coils and α-helixes, but no β sheets. Furthermore, IL-32 contains an RGD motif, which potentially activates procaspase-3 intracellular and or binds to integrins. Mutation of the RGD motif...
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