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Article

The former annotated human pseudogene dihydrofolate reductase-like 1 (DHFRL1) is expressed and functional.

Proceedings of the National Academy of Sciences of the United States of America - 13 Sept 2011

McEntee Gráinne, Minguzzi Stefano, O'Brien Kirsty, Ben Larbi Nadia, Loscher Christine, O'Fágáin Ciarán, Parle-McDermott Anne

Abstract excerpt

Human dihydrofolate reductase (DHFR) was previously thought to be the only enzyme capable of the reduction of dihydrofolate to tetrahydrofolate; an essential reaction necessary to ensure a continuous supply of biologically active folate. DHFR has been studied extensively from a number of perspectives because of its role in health and disease. Although the presence of a number of intronless DHFR pseudogenes has...

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Identifiers

PMID: 21876184
DOI: 10.1073/pnas.1103605108
PMCID: PMC3174580

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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