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Article

How to deal with the early GWAS data when imputing and combining different arrays is necessary.

European journal of human genetics : EJHG - 1 May 2012

Uh Hae-Won, Deelen Joris, Beekman Marian, Helmer Quinta, Rivadeneira Fernando, Hottenga Jouke-Jan, Boomsma Dorret I, Hofman Albert, Uitterlinden André G, Slagboom P E, Böhringer Stefan, Houwing-Duistermaat Jeanine J

Abstract excerpt

Genotype imputation has become an essential tool in the analysis of genome-wide association scans. This technique allows investigators to test association at ungenotyped genetic markers, and to combine results across studies that rely on different genotyping platforms. In addition, imputation is used within long-running studies to reuse genotypes produced across generations of platforms. Typically, genotypes of...

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PMID: 22189269
DOI: 10.1038/ejhg.2011.231
PMCID: PMC3330212

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