Article
Malignant B cells induce the conversion of CD4+CD25- T cells to regulatory T cells in B-cell non-Hodgkin lymphoma.
PloS one - 1 Jan 2011
Han Yixiang, Wu Jianbo, Bi Laixi, Xiong Shudao, Gao Shenmeng, Yin Lihui, Jiang Lei, Chen Chiqi, Yu Kang, Zhang Shenghui
Abstract excerpt
Recent evidence has demonstrated that regulatory T cells (Treg) were enriched in the tumor sites of patients with B-cell non-Hodgkin lymphoma (NHL). However, the causes of enrichment and suppressive mechanisms need to be further elucidated. Here we demonstrated that CD4(+)CD25(+)FoxP3(+)CD127(lo) Treg were markedly increased and their phenotypes were different in peripheral blood (PB) as well as bone marrow (BM)...
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