Article
Sequential adaptive mutations enhance efficient vector switching by Chikungunya virus and its epidemic emergence.
PLoS pathogens - 1 Dec 2011
Tsetsarkin Konstantin A, Weaver Scott C
Abstract excerpt
The adaptation of Chikungunya virus (CHIKV) to a new vector, the Aedes albopictus mosquito, is a major factor contributing to its ongoing re-emergence in a series of large-scale epidemics of arthritic disease in many parts of the world since 2004. Although the initial step of CHIKV adaptation to A. albopictus was determined to involve an A226V amino acid substitution in the E1 envelope glycoprotein that first...
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