Article
Lineage Divergence and Vector-Specific Adaptation Have Driven Chikungunya Virus onto Multiple Adaptive Landscapes.
mBio - 21 Dec 2021
Chen Rubing, Plante Jessica A, Plante Kenneth S, Yun Ruimei, Shinde Divya, Liu Jianying, Haller Sherry, Mukhopadhyay Suchetana, Weaver Scott C
Abstract excerpt
Previous studies have shown that the adaptation of Indian Ocean lineage (IOL) chikungunya virus (CHIKV) strains for Aedes albopictus transmission was mediated by an E1-A226V substitution, followed by either a single substitution in E2 or synergistic substitutions in the E2 and E3 envelope glycoproteins. Here, we examined whether Asian lineage strains, including those that descended from the 2014 Caribbean...
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