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Article

ES cell differentiation system recapitulates the establishment of imprinted gene expression in a cell-type-specific manner.

Human molecular genetics - 15 Mar 2012

Kohama Chihiro, Kato Hidemasa, Numata Koji, Hirose Michiko, Takemasa Tohru, Ogura Atsuo, Kiyosawa Hidenori

Abstract excerpt

Genomic imprinting is a phenomenon whereby monoallelic gene expression occurs in a parent-of-origin-specific manner. A subset of imprinted genes acquires a tissue-specific imprinted status during the course of tissue development, and this process can be analyzed by means of an in vitro differentiation system utilizing embryonic stem (ES) cells. In neurons, the gene Ube3a is expressed from the maternal allele...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22156770
DOI: 10.1093/hmg/ddr577

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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