Article
A novel microsatellite polymorphism of sodium channel beta1-subunit gene (SCN1B) may underlie abnormal cardiac excitation manifested by coved-type ST-elevation compatible with Brugada syndrome in Japanese.
International journal of clinical pharmacology and therapeutics - 1 Feb 2010
Ogawa R, Kishi R, Takagi A, Sakaue I, Takahashi H, Matsumoto N, Masuhara K, Nakazawa K, Kobayashi S, Miyake F, Echizen H
Abstract excerpt
OBJECTIVE: Brugada syndrome (BrS) is a rare sodium channelopathy typically seen in middle-aged, Southeast Asian males conferring high risks of cardiac sudden death. Loss-of-function mutations in SCN5A encoding the alpha-subunit of cardiac sodium channels may account partially for its etiology. We...
Topics
- Adult
- Age Factors
- Aged
- Asian People
- Brugada Syndrome
- Electrocardiography
- Female
- Genetic Predisposition to Disease
- Humans
- Japan
- Lidocaine
- Logistic Models
- Male
- Microsatellite Repeats