Article
Potent and selective activation of abscisic acid receptors in vivo by mutational stabilization of their agonist-bound conformation.
Proceedings of the National Academy of Sciences of the United States of America - 20 Dec 2011
Mosquna Assaf, Peterson Francis C, Park Sang-Youl, Lozano-Juste Jorge, Volkman Brian F, Cutler Sean R
Abstract excerpt
Pyrabactin resistance (PYR) 1 and its relatives belong to a family of soluble abscisic acid (ABA) receptors that inhibit type 2C protein phosphatases (PP2C) when in their agonist-stabilized conformation. Given their switch-like properties, we envisioned that mutations that stabilize their agonist-bound conformation could be used to activate signaling in vivo. To identify such mutations, we subjected PYR1 to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.