Article
Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins.
Science (New York, N.Y.) - 22 May 2009
Park Sang-Youl, Fung Pauline, Nishimura Noriyuki, Jensen Davin R, Fujii Hiroaki, Zhao Yang, Lumba Shelley, Santiago Julia, Rodrigues Americo, Chow Tsz-Fung F, Alfred Simon E, Bonetta Dario, Finkelstein Ruth, Provart Nicholas J, Desveaux Darrell, Rodriguez Pedro L, McCourt Peter, Zhu Jian-Kang, Schroeder Julian I, Volkman Brian F, Cutler Sean R
Abstract excerpt
Type 2C protein phosphatases (PP2Cs) are vitally involved in abscisic acid (ABA) signaling. Here, we show that a synthetic growth inhibitor called pyrabactin functions as a selective ABA agonist. Pyrabactin acts through PYRABACTIN RESISTANCE 1 (PYR1), the founding member of a family of START proteins called PYR/PYLs, which are necessary for both pyrabactin and ABA signaling in vivo. We show that ABA binds to...
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