Article
Epigenomic deregulation in the immune system.
Epigenomics - 1 Dec 2011
Rodriguez-Cortez Virginia C, Hernando Henar, de la Rica Lorenzo, Vento Roser, Ballestar Esteban
Abstract excerpt
Proper immune function is the result of multiple cell commitment and differentiation steps, and adequate control of activation mechanisms. Deregulation of transcriptional programs in immune cells leads to the development of hematological malignancies, autoimmune diseases or immunodeficiencies. In this sense, epigenetic control of gene expression plays an essential role in the correct function of the immune system...
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