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Article

[Mutations in precore/basal core promoter regions and viral polymerase in patients with chronic hepatitis B].

Enfermedades infecciosas y microbiologia clinica - 1 Feb 2012

Gutiérrez Ainhoa, Viciana Isabel, Rius Francisca, Pinedo Alfonso

Abstract excerpt

BACKGROUND: Variations of C gene give rise to precore and basal core mutations, which influence HBeAg expression The antiviral treatment failure is due to the presence of variations in the gene P, which cause mutations in the viral polymerase. METHODS: We performed genotyping of HBV P gene by sequencing, and gene C in patients with chronic hepatitis B over a period of five years. RESULTS: A total of 75% of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22112677
DOI: 10.1016/j.eimc.2011.08.008

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