Article
A seven-transmembrane receptor that mediates avoidance response to dihydrocaffeic acid, a water-soluble repellent in Caenorhabditis elegans.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 16 Nov 2011
Aoki Reina, Yagami Tatsurou, Sasakura Hiroyuki, Ogura Ken-Ichi, Kajihara Yasuhiro, Ibi Masakazu, Miyamae Takeaki, Nakamura Fumio, Asakura Taro, Kanai Yoshikatsu, Misu Yoshimi, Iino Yuichi, Ezcurra Marina, Schafer William R, Mori Ikue, Goshima Yoshio
Abstract excerpt
The ability to detect harmful chemicals rapidly is essential for the survival of all animals. In Caenorhabditis elegans (C. elegans), repellents trigger an avoidance response, causing animals to move away from repellents. Dihydrocaffeic acid (DHCA) is a water-soluble repellent and nonflavonoid catecholic compound that can be found in plant products. Using a Xenopus laevis (X. laevis) oocyte expression system, we...
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