Article
Mutations in the gene encoding p62 in Japanese patients with amyotrophic lateral sclerosis.
Neurology - 29 Jan 2013
Hirano Makito, Nakamura Yusaku, Saigoh Kazumasa, Sakamoto Hikaru, Ueno Shuichi, Isono Chiharu, Miyamoto Katsuichi, Akamatsu Maiko, Mitsui Yoshiyuki, Kusunoki Susumu
Abstract excerpt
OBJECTIVE: The purpose of this study was to find mutations in the SQSTM1 gene encoding p62 in Japanese patients with amyotrophic lateral sclerosis (ALS), since this gene has been recently identified as a causative gene for familial and sporadic ALS in the United States. METHODS: We sequenced this gene in 61 Japanese patients with sporadic and familial ALS. To our knowledge, we describe for the first time the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.