Article
Identification of a methylation hotspot in the death receptor Fas/CD95 in bladder cancer.
International journal of oncology - 1 Mar 2012
Watson C J, O'Kane H, Maxwell P, Sharaf O, Petak I, Hyland P L, O'Rouke D, McKnight J, Canning P, Williamson K
Abstract excerpt
We characterized Fas immunoreactivity, functionality and its role in the response to mitomycin-C (MMC) chemotherapy in vitro in cell lines and in vivo in bladder washings from 23 transitional cell carcinoma of the bladder (TCCB) patients, harvested prior to and during MMC intravesical treatment. Having established the importance of functional Fas, we investigated the methylation and exon 9 mutation as mechanisms...
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