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Gallium compound GaQ 3 ‐induced Ca 2+ signalling triggers p53‐dependent and ‐independent apoptosis in cancer cells

10 Nov 2011

Abstract excerpt

BACKGROUND AND PURPOSE A novel anti-neoplastic gallium complex GaQ(3) (KP46), earlier developed by us, is currently in phase I clinical trial. GaQ(3) induced S-phase arrest and apoptosis via caspase/PARP cleavage in a variety of cancers. However, the underlying mechanism of apoptosis is unknown. Here, we have explored the mechanism(s) of GaQ(3) -induced apoptosis in cancer cells, focusing on p53 and intracellular...

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PMID: 22074401
DOI: 10.1111/j.1476-5381.2011.01780.x

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