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Article

Drosophila duplication hotspots are associated with late-replicating regions of the genome.

PLoS genetics - 1 Nov 2011

Cardoso-Moreira Margarida, Emerson J J, Clark Andrew G, Long Manyuan

Abstract excerpt

Duplications play a significant role in both extremes of the phenotypic spectrum of newly arising mutations: they can have severe deleterious effects (e.g. duplications underlie a variety of diseases) but can also be highly advantageous. The phenotypic potential of newly arisen duplications has stimulated wide interest in both the mutational and selective processes shaping these variants in the genome. Here we...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 22072977
DOI: 10.1371/journal.pgen.1002340
PMCID: PMC3207856

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Source receipt: pubmed, retrieved 7 Sept 2026.

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