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Rab27a GTPase and its effector Myosin Va are host factors required for efficient Oropouche virus cell egress

30 Aug 2024

Abstract excerpt

Oropouche fever, a debilitating illness common in South America, is caused by Oropouche virus (OROV), an arbovirus. OROV belongs to the Peribunyaviridae family, a large group of RNA viruses. Little is known about the biology of Peribunyaviridae in host cells, especially assembly and egress processes. Our research reveals that the small GTPase Rab27a mediates intracellular transport of OROV induced compartments...

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PMID: 39213446
DOI: 10.1371/journal.ppat.1012504

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