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Article

Msx1 and Msx2 promote meiosis initiation.

Development (Cambridge, England) - 1 Dec 2011

Le Bouffant Ronan, Souquet Benoit, Duval Nathalie, Duquenne Clotilde, Hervé Roxane, Frydman Nelly, Robert Benoit, Habert René, Livera Gabriel

Abstract excerpt

The mechanisms regulating germ line sex determination and meiosis initiation are poorly understood. Here, we provide evidence for the involvement of homeobox Msx transcription factors in foetal meiosis initiation in mammalian germ cells. Upon meiosis initiation, Msx1 and Msx2 genes are strongly expressed in the foetal ovary, possibly stimulated by soluble factors found there: bone morphogenetic proteins Bmp2 and...

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Identifiers

PMID: 22071108
DOI: 10.1242/dev.068452

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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