Article
Coronary artery disease in a Werner syndrome-like form of progeria characterized by low levels of progerin, a splice variant of lamin A.
American journal of medical genetics. Part A - 1 Dec 2011
Hisama Fuki M, Lessel Davor, Leistritz Dru, Friedrich Katrin, McBride Kim L, Pastore Matthew T, Gottesman Gary S, Saha Bidisha, Martin George M, Kubisch Christian, Oshima Junko
Abstract excerpt
Classical Hutchinson-Gilford progeria syndrome (HGPS) is caused by LMNA mutations that generate an alternatively spliced form of lamin A, termed progerin. HGPS patients present in early childhood with atherosclerosis and striking features of accelerated aging. We report on two pedigrees of adult-onset coronary artery disease with progeroid features, who were referred to our International Registry of Werner...
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