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Article

SOHLH1 and SOHLH2 control Kit expression during postnatal male germ cell development.

1 Jan 2012

Abstract excerpt

How Kit expression is regulated in the germline remains unknown. SOHLH1 and SOHLH2, two bHLH transcription factors specifically expressed in germ cells, are involved in spermatogonia and oocyte differentiation. In the male, deletion of each factor causes loss of Kit-expressing spermatogonia in the prepuberal testis. In the female, SOHLH1 and SOHLH2 ablations cause oocyte loss in the neonatal ovary. To investigate...

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Identifiers

PMID: 22328502
DOI: 10.1242/jcs.092593

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