Article
A new Prospero and microRNA-279 pathway restricts CO2 receptor neuron formation.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Nov 2011
Hartl Marion, Loschek Laura F, Stephan Daniel, Siju K P, Knappmeyer Christiane, Kadow Ilona C Grunwald
Abstract excerpt
CO(2) sensation represents an interesting example of nervous system and behavioral evolutionary divergence. The underlying molecular mechanisms, however, are not understood. Loss of microRNA-279 in Drosophila melanogaster leads to the formation of a CO(2) sensory system partly similar to the one of mosquitoes. Here, we show that a novel allele of the pleiotropic transcription factor Prospero resembles the miR-279...
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