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Article

Association of IL-12B genetic polymorphism with the susceptibility and disease severity of ankylosing spondylitis.

The Journal of rheumatology - 1 Jan 2012

Wong Ruey-Hong, Wei James Cheng-Chung, Huang Chun-Huang, Lee Hong-Shen, Chiou Shang-Yan, Lin Shin-Hua, Cai Yan-Wei, Hung Pei-Hsuan, Wang Ming-Fuu, Yang Shun-Fa

Abstract excerpt

OBJECTIVE: Interleukin 23 (IL-23) stimulates the differentiation of T helper 17 (Th17) cells, which are involved in the pathogenesis of ankylosing spondylitis (AS). Binding of IL-23 to the IL-23 receptor complex activates Janus kinases 2 and tyrosine kinase 2, which phosphorylate IL-23R and subsequently promote the transcription of the IL-17 gene. IL-12B encodes a p40 subunit common to IL-12 and IL-23. We...

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Share to Gene Frequency
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Interleukin-12 Subunit p40

Share to Polymorphism, Genetic

Share to Receptors, Interleukin

Share to Severity of Illness Index

Share to Spondylitis, Ankylosing

Source

Identifiers

PMID: 22045842
DOI: 10.3899/jrheum.110613

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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