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Article

Conformational studies of immunodominant myelin basic protein 1-11 analogues using NMR and molecular modeling.

Journal of computer-aided molecular design - 1 Nov 2011

Laimou Despina, Lazoura Eliada, Troganis Anastassios N, Matsoukas Minos-Timotheos, Deraos Spyros N, Katsara Maria, Matsoukas John, Apostolopoulos Vasso, Tselios Theodore V

Abstract excerpt

Τwo dimensional nuclear magnetic resonance studies complimented by molecular dynamics simulations were conducted to investigate the conformation of the immunodominant epitope of acetylated myelin basic protein residues 1-11 (Ac-MBP(1-11)) and its altered peptide ligands, mutated at position 4 to an alanine (Ac-MBP(1-11)[4A]) or a tyrosine residue (Ac-MBP(1-11)[4Y]). Conformational analysis of the three analogues...

Read the complete abstract on PubMed

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Share to Encephalomyelitis, Autoimmune, Experimental
Share to Genes, MHC Class II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Dynamics Simulation

Share to Myelin Basic Protein

Share to Nuclear Magnetic Resonance, Biomolecular

Share to Peptide Fragments

Share to Peptides

Share to Receptors, Antigen, T-Cell

Source

Identifiers

PMID: 22042377
DOI: 10.1007/s10822-011-9481-6

Genes

MBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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