Article
Novel oligomannose liposome-DNA complex DNA vaccination efficiently evokes anti-HPV E6 and E7 CTL responses.
Experimental and molecular pathology - 1 Feb 2012
Mizuuchi Masahito, Hirohashi Yoshihiko, Torigoe Toshihiko, Kuroda Takafumi, Yasuda Kazuyo, Shimizu Yoshitaka, Saito Tsuyoshi, Sato Noriyuki
Abstract excerpt
The aim of this study was to establish an efficient human papilloma virus (HPV) type 16-targeting cancer immunotherapy. Persistent high-risk HPV infection causes cervical intra-epithelial neoplasia (CIN) and subsequent cervical carcinoma. HPV type16 (HPV16) is one of the common carcinogenic types and is found in about 50% of invasive cervical carcinomas. HPV16-derived viral proteins E6 and E7 are expressed in...
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