Article
Mannan structural complexity is decreased when Candida albicans is cultivated in blood or serum at physiological temperature.
Carbohydrate research - 13 Dec 2011
Lowman Douglas W, Ensley Harry E, Greene Rachel R, Knagge Kevin J, Williams David L, Kruppa Michael D
Abstract excerpt
The Candida albicans cell wall provides an architecture that allows for the organism to survive environmental stress as well as interaction with host tissues. Previous work has focused on growing C. albicans on media such as Sabouraud or YPD at 30°C. Because C. albicans normally colonizes a host, we hypothesized that cultivation on blood or serum at 37°C would result in structural changes in cell wall mannan. C....
Topics
- Animals
- Blood
- Candida albicans
- Carbohydrate Conformation
- Carbohydrate Sequence
- Cell Wall
- Culture Media
- Magnetic Resonance Spectroscopy
- Mannans
- Molecular Sequence Data
- Phenotype
- Sheep
- Temperature