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Article

Restriction of trophic factors and nutrients induces PARKIN expression

25 Oct 2011

Abstract excerpt

Parkinson's disease (PD) is the most frequent neurodegenerative movement disorder and manifests at old age. While many details of its pathogenesis remain to be elucidated, in particular the protein and mitochondrial quality control during stress responses have been implicated in monogenic PD variants. Especially the mitochondrial kinase PINK1 and the ubiquitin ligase PARKIN are known to cooperate in autophagy...

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PMID: 22028146
DOI: 10.1007/s10048-011-0303-8

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