Article
Hypothalamic mitochondrial dysfunction associated with anorexia in the anx/anx mouse.
Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 2011
Lindfors Charlotte, Nilsson Ida A K, Garcia-Roves Pablo M, Zuberi Aamir R, Karimi Mohsen, Donahue Leah Rae, Roopenian Derry C, Mulder Jan, Uhlén Mathias, Ekström Tomas J, Davisson Muriel T, Hökfelt Tomas G M, Schalling Martin, Johansen Jeanette E
Abstract excerpt
The anorectic anx/anx mouse exhibits disturbed feeding behavior and aberrances, including neurodegeneration, in peptidergic neurons in the appetite regulating hypothalamic arcuate nucleus. Poor feeding in infants, as well as neurodegeneration, are common phenotypes in human disorders caused by dysfunction of the mitochondrial oxidative phosphorylation system (OXPHOS). We therefore hypothesized that the anorexia...
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