Article
Altered dopaminergic transmission in the anorexic anx/anx mouse striatum.
Neuroreport - 28 Aug 2001
Johansen J E, Teixeira V L, Johansson C, Serrão P, Berggren P O, Soares-Da-Silva P, Schalling M, Bertorello A M
Abstract excerpt
We demonstrate abnormal dopaminergic neurotransmission in anorexic mice, homozygous for a recessive mutation (anx) causing starvation and motor disturbances. Isolated neurons from anx/anx striatum displayed a markedly increased activity of the Na+,K+-ATPase compared with normal littermates. Dopamine down-regulates Na+,K+-ATPase activity in striatal medium spiny neurons in rat, mouse and guinea pig. However,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
