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Elevated Levels of Cell-Free Circulating DNA in Patients with Acute Dengue Virus Infection

7 Oct 2011

Abstract excerpt

BACKGROUND: Apoptosis is thought to play a role in the pathogenesis of severe dengue and the release of cell-free DNA into the circulatory system in several medical conditions. Therefore, we investigated circulating DNA as a potential biomarker for severe dengue. METHODS AND FINDINGS: A direct fluorometric degradation assay using PicoGreen was performed to quantify cell-free DNA from patient plasma. Circulating...

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PMID: 22016795
DOI: 10.1371/journal.pone.0025969

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