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PRINCIPLE: a tool for associating genes with diseases via network propagation.

Bioinformatics (Oxford, England) - 1 Dec 2011

Gottlieb Assaf, Magger Oded, Berman Igor, Ruppin Eytan, Sharan Roded

Abstract excerpt

SUMMARY: PRINCIPLE is a Java application implemented as a Cytoscape plug-in, based on a previously published algorithm, PRINCE. Given a query disease, it prioritizes disease-related genes based on their closeness in a protein-protein interaction network to genes causing phenotypically similar disorders to the query disease. AVAILABILITY: Implemented in Java, PRINCIPLE runs over Cytoscape 2.7 or newer versions....

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PMID: 22016407
DOI: 10.1093/bioinformatics/btr584

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